This puzzle is about efficiency: getting one letter to do the work of many. The two sets of clues can be matched so that a string of two or more letters in the answer from the left can be replaced by a single letter in the answer on the right. (As a guide, the twenty-five letters are all different.) The clues, correctly matched with their answers and ordered by the right column, are:
| Left clue | Right clue | Left ans. | Right ans. | String | Ltr |
|---|---|---|---|---|---|
| Alaskan Eskimo | Stop | INuit | quit | IN | Q |
| Ashore, like a whale | Vandyke, e.g. | beaCHEd | beard | CHE | R |
| Sleeveless women's garment | Persuade | caMISole | cajole | MIS | J |
| Food storage area | Spasm | panTRY | pang | TRY | G |
| Michigan city | Superfluous (2 wds.) | detroIT | de trop | IT | P |
| Worked in marble | Offspring | chiSELEd | child | SELE | L |
| Change chemically (as with yeast) | E.B. White character | ferMENT | fern | MENT | N |
| Large wine bottle | Certain gift bearers | magNUM | magi | NUM | I |
| Maturation period | Crevice filler | puBERty | putty | BER | T |
| Dog | A dessert | caNINe | cake | NIN | K |
| Earth goddess | Hesitation | demETEr | demur | ETE | U |
| Show passion or fervor | Join | ENTHuse | fuse | ENTH | F |
| Forefather | Fix | ancESTor | anchor | EST | H |
| Hero worshipper? | A machine | leANDer | lever | AND | V |
| Doric or Ionic | Legislature | diALECt | diet | ALEC | E |
| Beast | Fold | creaTURe | crease | TUR | S |
| Snake | Aroma | sERPent | scent | ERP | C |
| Exterior | Laughing gas is one | oUTSide | oxide | UTS | X |
| Hold together | Arrive | coHERe | come | HER | M |
| Scope | Shower alternative | bREADth | bath | READ | A |
| Move around, as at a party | Chocolate sauce | mINGle | mole | ING | O |
| Lemur, for instance | Value | priMATe | prize | MAT | Z |
| Barren | Fashion | stERIle | style | ERI | Y |
| Reclusive author | Someone at a wife-swapping party | sALinger | swinger | AL | W |
| Big name in trains | Possible Hearst crime? | liONel | libel | ON | B |
The replaced strings spell out "In chemistry, it's element number nineteen / The stand a lecturer puts her reading material on". These are clues for another pair of words where a letter can replace a string, "potassium" and "podium". This gives the unused letter (d) and the answer, which is TASS.